The 9aaTAD activation domains in the four Yamanaka Oct4, Sox2, Myc, and Klf4 transcription factors essential during the stem cell development

Piskacek M, Jendruchova K, Rezacova M, Havelka M, Gasparik N, Hofrova A, Knight A

BioRxiv (2019) doi.org/10.1101/2019.12.15.876706

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​​​The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs

Piskacek M, Havelka M, Jendruchova K, Knight A, Keegan LP

Cellular and Molecular Life Sciences (2019) doi: 10.1007/s00018-019-03251-w

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​​​Nuclear Hormone Receptors: ancient 9aaTAD and evolutionally gained NCoA Activation Pathways

Piskacek M, Havelka M, Jendruchova K, Knight A

Journal of Steroid Biochemistry and Molecular Biology (2018) doi.org/10.1016/j.jsbmb.2018.11.008

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The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

Fafilek B, Balek L, Bosakova MK, Varecha M, Nita A, Gregor T, Gudernova I, Krenova J, Ghosh S, Piskacek M,

Jonatova L, Cernohorsky NH, Zieba JT, Kostas M, Haugsten EM, Wesche J, Erneux C, Trantirek L, Krakow D, Krejci P.

Sci Signal (2018) doi: 10.1126/scisignal.aap8608

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​​​Gal4 activation domain 9aaTAD could be inactivated by adjacent mini-inhibitory domain and reactivated by distal re-activation domain

Piskacek M, Havelka M, Rezacova M, Knight A

BioRxiv (2017) doi.org/10.1101/110882

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The 9aaTAD is exclusive activation domain in Gal4

Piskacek M, Havelka M, Rezacova M, Knight A

PlosOne (2017) doi: 10.1371/journal.pone.0169261

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The 9aaTAD Transactivation Domains: from Gal4 to p53

Piskacek M, Havelka M, Rezacova M, Knight A

PlosOne (2016) doi: 10.1371/journal.pone.0162842

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Do human B-lymphocytes avoid aging until 60 years?

Knight A, Nemec P, Bretzova S, Valkova L, Kolmanova K, Vytopilova R, Havelka M,

Vsianska P, Rihova L, Krejci M and Piskacek M

Oncotarget (2016) doi: 10.18632/oncotarget.10146

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Shared structural features of the 9aaTAD family in complex with CBP

Piskacek M, Vasku A, Hajek R and Knight A

Molecular BioSystems (2014) doi: 10.1039/c4mb00672k

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​Functionally suppressive CD8 T regulatory cells are increased in patients

with multiple myeloma: a cause for immune impairment
Muthu Raja KR, Kubiczkova L, Rihova L, Piskacek M, Vsianska P, Hezova R, Pour L, Hajek R
PLoS One (2012)​ doi: 10.1371/journal.pone.0049446
 

Conditional Knock-down of the Mitochondrial Magnesium Channel hMrs2
Piskacek M, Zotova L, Zsurka G and Schweyen RJ
Journal of Cellular and Molecular Medicine (2009) ​doi: 10.1111/j.1582-4934.2008.00328.x
 

Nine-amino-acid transactivation domain: Establishment and prediction utilities
Piskacek S, Gregor M, Nemethova M, Grabner M, Kovarik P, Piskacek M
Genomics (2007)​ doi: 10.1016/j.ygeno.2007.02.003
 

A novel 9-amino-acid transactivation domain in the C-terminal part of Sox18
Sandholzer J, Hoeth M, Piskacek M, Mayer H, de Martin R
Biochem Biophys Res Commun (2007)​ doi: 10.1016/j.bbrc.2007.06.095
 

Predicting the function and subcellular location of Caenorhabditis elegans proteins
Gurvitz A, Langer S, Piskacek M, Hamilton B, Ruis H, Hartig A
Yeast (2000)​ doi: 10.1002/1097-0061(20000930)17:3<188::AID-YEA27>3.0.CO;2-E
 

Functional analysis of the Zn(2)Cys(6) transcription factors Oaf1p and Pip2p
Baumgartner U, Hamilton B, Piskacek M, Ruis H, Rottensteiner H
J Biol Chem (1999)​ doi: 10.1074/jbc.274.32.22208
 

Common Transactivation Motif 9aaTAD recruits multiple general co-activator

Piskacek M, Nature Precedings (2009)

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Rsp5 promotes Gene Activation mediated by 9aaTAD Transcription Factors Oaf1 and Gal4

Lipp J, Koranda M, Piskacek M, Nature Precedings (2009)

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9aaTAD Prediction result (2006)

Piskacek M, Nature Precedings (2009)​